ZIKV-IN-6

• Description :

  ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC50 > 50 μM) . ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis[1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis; Flavivirus

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/zikv-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1C2=C(C(O)=C(N3CCC(C4=CC=CC=C4)CC3)C=C2O)C(C5=C1C[C@@](C)(O)[C@@](C)(O)C5)=O

• Molecular Formula :

  C27H29NO6

• Molecular Weight :

  463.52

• References & Citations :

  [1]Zhu Y, et al. Design, synthesis, and biological evaluation of a series of new anthraquinone derivatives as anti-ZIKV agents. Eur J Med Chem. 2023 Oct 5;258:115620.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported