CDK4/6-IN-17

• UNSPSC Description:

  CDK4/6-IN-17 (Compound 12) is a CDK4/6 inhibitor (IC50: 50: 10-100 nM) . CDK4/6-IN-17 inhibits tumor growth in COLO205 xenograft tumors[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk4-6-in-17.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC([C@H]1N2C3=CC(C4=NC(NC5=CC=C(C=N5)CN6CCN(CC6)CC)=NC=C4F)=CC(F)=C3N=C2CC1)F

• Molecular Weight:

  540.56

• References & Citations:

  [1]Zhao X, et al. Preparation of benzopyrroloimidazolyl compounds as CDK4/6 kinase inhibitors. World Intellectual Property Organization, WO2016173505 A1. 2016-11-03.|[2]Zhao Xingdong. A kind of kinase inhibitor. Patent. CN107849012.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2035069-96-4