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CDK4/6-IN-26

CAT: 0804-HY-179151Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179151Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK4/6-IN-26 is a carbamate derivative that targets CDK4/CDK6. CDK4/6-IN-26 reduces CDK4/CDK6 levels, resulting in cell cycle arrest in the G0/G1 phase and in the S phase. CDK4/6-IN-26 exhibits high potency against SW480 cells (IC50 = 6.3 μM) . CDK4/6-IN-26 affects ROS levels by increasing the expression of SOD2/MnSOD. CDK4/6-IN-26 establishes several interactions with the amino acids of the CDK6 active site. CDK4/6-IN-26 can be used for the research of colorectal cancer[1].
UNSPSC
12352005
Target
CDK; Reactive Oxygen Species (ROS) ; SOD
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC(C1=C(OC(C)=O)C(OC(C)=O)=C2[C@@]3(NC(OCC(C)C)=O)CCCC(C)(C)[C@]3([H])CCC2=C1)C
Molecular Formula
C28H41NO6
Molecular Weight
487.63
References & Citations
[1]Moura SPSP, et al. Synthesis and biological evaluation of novel carnosic acid derivatives with anticancer activity. RSC Adv. 2025 Oct 6;15 (44) :36861-36878.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

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