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CDK4/6-IN-8

CAT: 0804-HY-143258Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143258Size:1 Each
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Description
CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1].
CAS Number
2649120-22-7
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C([N+]([O-])=O)C=C1)NNC(N2CCC[C@@H]2C(NC3=CC=CN=C3)=O)=O
Molecular Formula
C18H18N6O5
Molecular Weight
398.37
References & Citations
[1]Liang JW, et al. Synthesis and identification of a novel skeleton of N- (pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities. Bioorg Chem. 2022 Feb;119:105547.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

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