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TLR7/8 agonist 12

CAT: 0804-HY-170770Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170770Size:1 Each
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Description
TLR7/8 agonist 12 (compound 9) is an hTLR7/8 agonist, with EC50 values of 11 nM (hTLR7) and 150 nM (hTLR8), respectively. TLR7/8 agonist 12 has the potential for immunomodulation[1].
CAS Number
3080931-00-3
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OCC[C@H](CCC)NC1=NC(N)=NC2=C1N(CC3=C(OC)C=CC(CN[C@@H]4COCC4)=C3)C5=C2C=CC=C5
Molecular Formula
C29H38N6O3
Molecular Weight
518.65
References & Citations
[1]Poudel YB, et al. Structure-Based Design of Novel TLR7/8 Agonist Payloads Enabling an Immunomodulatory Conjugate Approach. ACS Med Chem Lett. 2024 Dec 19;16 (1) :80-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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