TLR7/8 agonist 11

TLR7/8 agonist 11

• UNSPSC Description: TLR7/8 agonist 11 (compound 30) is a potent agonist of hTLR7 and hTLR8, with EC50s of 31.1 nM and 13.1 nM, respectively. TLR7/8 agonist 11 plays an important role in adaptive and innate immune responses[1].
• Target Antigen: Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/tlr7-8-agonist-11.html
• Smiles: NC1=NC2=CN(N=C2C(N[C@H](CO)CCC)=N1)CC3=CC=C(C=C3OC)CN(C(CC4=CC=CN=C4)C)C
• Molecular Weight: 518.65
• References & Citations: [1]Akash M Patel, et al. Design and Optimization of Selectivity-Tunable Toll-like Receptor 7/8 Agonists as Novel Antibody–Drug Conjugate Payloads. J Med Chem. 2024 Sep 12;67(17):15756-15779.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported