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TLR7/8 agonist 13

CAT: 0013-GTR19264714-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264714-01Size:10 mg
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Description
TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (with a lowest effective concentration (LEC) [hTLR7] of 1.6 μM) and TLR8 (LEC [hTLR8] of 1.6 μM) . It acts on human peripheral blood mononuclear cells (hPBMC) with agonistic activity (LEC [hPBMC] = 0.5 μM) . In mice and cynomolgus monkeys, TLR7/8 agonist 13 induces endogenous IFNα, activates myeloid dendritic cells and monocytes, promoting their differentiation towards a TH1 phenotype. In chronic AAV-HBV mouse models, it reduces viral load and HBV surface antigen levels. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, facilitating the response of HBV antigen-specific CD8 T cells. This compound is useful for hepatitis B virus research.
CAS Number
1402802-45-2
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery; Cell Biology
Smiles
N ([C@@H] (CCCC) CCO) C=1C (OC) =CN=C (N) N1
Molecular Formula
C12H22N4O2
Molecular Weight
254.33
Storage Conditions
-20°C
Notes
For research use only.

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