ATR-IN-20

CAT: 0804-HY-151915Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-151915Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

ATR-IN-20 is a potent ATR (ATM/ATR) inhibitor with an IC50 of 3 nM. ATR-IN-20 possess an inhibitory effect on mTOR (IC50 of 18 nM) while displaying good selectivity against PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM) . ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects[1].

CAS Number

3012609-63-8

UNSPSC

12352005

Target

ATM/ATR; mTOR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atr-in-20.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C(C)(C)C2=NC(C3=CC=CC4=C3C=CN4)=NC(N5[C@H](C)COCC5)=C2C1)C6=CC=CC(S(=O)(C)=O)=C6

Molecular Formula

C29H31N5O4S

Molecular Weight

545.65

References & Citations

[1]Yinliang Qi, et al. Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design. Eur J Med Chem. 2022 Nov 26;246:114945.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ATM; ATR; mTOR

Related Products

Catalog	Name
HY-161616	ATR-IN-30
HY-142671	ATR-IN-5
HY-147569	ATR-IN-17
HY-147568	ATR-IN-16
HY-153729	ATR-IN-29
HY-171745	ATR-IN-32
HY-147566	ATR-IN-14
HY-147570	ATR-IN-18
HY-153393	ATR-IN-21
HY-142924	ATR-IN-8

Alternative Products

Catalog	Name
T73301-01	ATR-IN-20
520407-01	ATR
BA3714-10	ATR-IN-4
70R-15932	ATR antibody
T88133-01	ATR-IN-30
T61808-01	ATR-IN-14
T62233-01	ATR-IN-10
T62548-01	ATR-IN-17
MBS516559-01	ATR Protein
MBS3840342-01	ATR-101

ATR-IN-20

Related Products

Alternative Products

Popular Products