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ATR-IN-32

CAT: 0804-HY-171745Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171745Size:1 Each
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Description
ATR-IN-32 is an orally active ATR inhibitor. ATR-IN-32 potently inhibits the proliferation of MIA PaCa-2 cells. ATR-IN-32 exerts significant tumor growth inhibition in mice bearing LOVO and HT-29 xenografts. ATR-IN-32 can be used for the study of cancers mediated by ATR protein kinase, such as colorectal cancer, pancreatic cancer[1].
CAS Number
2902715-97-1
UNSPSC
12352005
Target
ATM/ATR
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Field of Research
Cancer
Purity
96.69
Smiles
N#CC1(CCOCC1)C2=CC(N3[C@@H](COCC3)C)=NC4=C2C=CN=C4C5=NNC=C5
Molecular Formula
C22H24N6O2
Molecular Weight
404.46
References & Citations
[1]XIE, Yuli, et al. NAPHTHYRIDINE DERIVATIVE AS ATR INHIBITOR AND METHOD FOR PREPARING SAME. PCT/CN2022/111893, WO2023/016529 A1. World Intellectual Property Organization (WIPO) International Bureau. 2023-02-16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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