ATR-IN-5

• UNSPSC Description:

  ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24)[1].

• Target Antigen:

  ATM/ATR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/atr-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNC1=NC2=CC=CC=C2N1C3=NC(N4[C@@H](COCC4)C)=CC(C5=C(N(C6CCNCC6)N=C5C)C(F)(F)F)=N3

• Molecular Weight:

  555.60

• References & Citations:

  [1]Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent CN112047938A.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2601571-19-9