ATR-IN-14

ATR-IN-14

• CAS Number: 2765785-88-2
• UNSPSC Description: ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].
• Target Antigen: ATM/ATR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/atr-in-14.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@@H]1COCCN1C2=NC3=C(N=CC(F)=C3C(C4=CC=NN4C)=C2)C5=CC=NN5
• Molecular Weight: 393.42
• References & Citations: [1]Shao-hui Wang, et al. Class of 1,7-naphthyridine compounds and application thereof. WO2022063308A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported