Topo I/COX-2-IN-1

Topo I/COX-2-IN-1

• CAS Number: 3031418-84-2
• UNSPSC Description: Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity[1].
• Target Antigen: Apoptosis; Prostaglandin Receptor; Topoisomerase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;GPCR/G Protein
• Applications: COVID-19-anti-virus
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/topo-i-cox-2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C=CC=C1NC2=CC=C(C=C2C(NCC3=CC=C(C(O)=C3)O)=O)F)Cl
• Molecular Weight: 400.83
• References & Citations: [1]Junfang Li, et al. N-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression. J Med Chem. 2022 Jul 22.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported