COX-2/PI3K-IN-1

COX-2/PI3K-IN-1

• UNSPSC Description: COX-2/PI3K-IN-1 (compound 5d) is a potent PI3K inhibitor with IC50 value of 1.14 nM. COX-2/PI3K-IN-1 is a selective COX-2 inhibitor with Ki value of 3.24 nM. COX-2/PI3K-IN-1 has anti-inflammatory and anti-cancer properties.
• Target Antigen: COX; PI3K
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PI3K/Akt/mTOR
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-pi3k-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: S=C(/N=C1C(N(C2=CC=CC=C2Cl)C3=C\1C=CC=C3)=S)NCN4C=CN=C4
• Molecular Weight: 411.93
• References & Citations: [1]Rajesh Kumar M, et al. p-TSA.H2O mediated one-pot, multi-component synthesis of isatin derived imidazoles as dual-purpose drugs against inflammation and cancer. Bioorg Chem. 2020 Sep;102:104046.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported