Topo I/COX-2-IN-2

Topo I/COX-2-IN-2

• CAS Number: 2841455-91-0
• UNSPSC Description: Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50 values of 0.90 μM and 2.31 μM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway[1].
• Target Antigen: Apoptosis; COX; Reactive Oxygen Species; Topoisomerase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/topo-i-cox-2-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=C(C(NC2=CC=CC=C2C(NC3=CC=C(C=C3)N4CCNCC4)=O)=CC=C1)C
• Molecular Weight: 420.93
• References & Citations: [1]Hu X, et al. Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy. Eur J Med Chem. 2022 Jun 23;240:114560.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported