Topo I-IN-1

Topo I-IN-1

• CAS Number: 2763655-68-9
• UNSPSC Description: Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis[1].
• Target Antigen: Apoptosis; Reactive Oxygen Species; Topoisomerase
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/topo-i-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NCC/C(C2=C1NC3=C2C=CC=C3)=C4C(NC5=C/4C=CC(Br)=C5)=O
• Molecular Weight: 408.25
• References & Citations: [1]Manasa Kadagathur, et al. Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors. Bioorg Chem. 2022 May;122:105706.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported