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BuChE-IN-5

CAT: 0804-HY-150585Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150585Size:1 Each
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Description
BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC50 value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation Aβ and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease[1].
CAS Number
2402753-39-1
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-5.html
Solubility
10 mM in DMSO
Smiles
N1(CC2=CC=CC=C2)CC(NCCN3CC(CC4=CC=CC=C4)CCC3)CC1
Molecular Formula
C25H35N3
Molecular Weight
377.57
References & Citations
[1]Wichur T, et al. 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2020 Feb 1;187:111916.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE

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