BuChE-IN-5

• Description:

  BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC50 value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation Aβ and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Cholinesterase (ChE) ; Tau Protein

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/buche-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N1(CC2=CC=CC=C2)CC(NCCN3CC(CC4=CC=CC=C4)CCC3)CC1

• Molecular Formula:

  C25H35N3

• Molecular Weight:

  377.57

• References & Citations:

  [1]Wichur T, et al. 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2020 Feb 1;187:111916.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BChE

• CAS Number:

  2402753-39-1