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Antimalarial agent 23

CAT: 0804-HY-149919Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149919Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-23.html
Solubility
10 mM in DMSO
Smiles
CCN(CC1=C(C=C(C=C1)Cl)O)CCNC2=NC=C3N=C(NC3=C2)C4=CC=CC(C(F)(F)F)=C4
Molecular Formula
C24H23ClF3N5O
Molecular Weight
489.92
References & Citations
[1]Henrietta D Attram, et al. Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies. ACS Infect Dis. 2023 Apr 14;9 (4) :928-942.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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