Antimalarial agent 23

• Description:

  Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/antimalarial-agent-23.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCN(CC1=C(C=C(C=C1)Cl)O)CCNC2=NC=C3N=C(NC3=C2)C4=CC=CC(C(F)(F)F)=C4

• Molecular Formula:

  C24H23ClF3N5O

• Molecular Weight:

  489.92

• References & Citations:

  [1]Henrietta D Attram, et al. Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies. ACS Infect Dis. 2023 Apr 14;9 (4) :928-942.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [9007-83-4]