Antimalarial agent 27

• Description:

  Antimalarial agent 27 (compound 11a) is an antimalarial agent, potently targeting to P.falciparum (IC50=0.37 μM) . Antimalarial agent 27 acts function via P.falciparum DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibition (IC50=0.11 μM) [1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/antimalarial-agent-27.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=CC=C1)N(C/C=C/P(O)(O[Na])=O)O

• Molecular Formula:

  C10H11NNaO5P

• Molecular Weight:

  279.16

• References & Citations:

  [1]Wang X, et al. MEPicides: α, β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase. ACS Infect Dis. 2023 Jul 14;9 (7) :1387-1395.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [9007-83-4]