HDAC-IN-63

CAT: 0804-HY-149474Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149474Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively) . HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML) [1].
CAS Number
[2920046-95-1]
UNSPSC
12352005
Target
Apoptosis; FLT3; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-63.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(Cl)=C1CN(C=N2)C3=C2C=CC(C4=CC(NC(CCCCCCC(NO)=O)=O)=NN4)=C3
Molecular Formula
C25H26Cl2N6O3
Molecular Weight
529.42
References & Citations
[1]Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-178022HDAC6-IN-63
HY-144292HDAC-IN-30
HY-161688HDAC-IN-73
HY-150597HDAC-IN-46
HY-18362HDAC-IN-5
HY-147966HDAC-IN-43
HY-144293HDAC-IN-31
HY-155182HDAC-IN-62
HY-146750HDAC-IN-37
HY-162910HDAC-IN-79

Alternative Products

CatalogName
MF-0147002-01HDAC-IN-63
MBS3606681-01HDAC-IN-4
MBS5815358HDAC-IN-49
MBS5815367HDAC-IN-51
MBS5800347HDAC-IN-26
MBS5803953HDAC-IN-32
MBS5804331HDAC-IN-42
MBS5804608HDAC-IN-35
MBS5804697HDAC-IN-30
MBS5804761HDAC-IN-47

Popular Products