HDAC-IN-63

CAT: 0804-HY-149474Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149474Size:1 Each
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AVAILABILITY: InStock
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Description
HDAC-IN-63 (Compound 63) is a dual FLT3/HDAC inhibitor (IC50: 0.844 and 30.0 nM for FLT3 and HDAC1 respectively) . HDAC-IN-63 inhibits MV4-11 cell proliferation (IC50: 92 nM. HDAC-IN-63 induces apoptosis and arrests cell cycle in MV4-11 cells. HDAC-IN-63 can be used for research of acute myeloid leukemia (AML) [1].
CAS Number
[2920046-95-1]
UNSPSC
12352005
Target
Apoptosis; FLT3; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-63.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC(Cl)=C1CN(C=N2)C3=C2C=CC(C4=CC(NC(CCCCCCC(NO)=O)=O)=NN4)=C3
Molecular Formula
C25H26Cl2N6O3
Molecular Weight
529.42
References & Citations
[1]Wang Z, et al. Rational discovery of dual FLT3/HDAC inhibitors as a potential AML therapy. Eur J Med Chem. 2023 Aug 28;260:115759.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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