NF-κB-IN-10

NF-κB-IN-10

• UNSPSC Description: NF-κB-IN-10 (compound E1) is an NF-κB inhibitor that can improve heart failure by reducing oxidative stress and inflammation by regulating Nrf2/NF-κB signaling pathway. NF-κB-IN-10 inhibits LPS-induced NO production and expression of iNOS and COX-2 in RAW264.7 cells. NF-κB-IN-10 can be used in the research of cardiovascular diseases[1].
• Target Antigen: NF-κB
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/nf-κb-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: CCCCOC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2C3=CC(C)=NN3C(C)=O
• Molecular Weight: 434.53
• References & Citations: [1]Yang X, et al. Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway. Eur J Med Chem. 2023 Oct 5;258:115602.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported