Mtb-IN-2

• Description :

  Mtb-IN-2 (compound 10c) is an antimicrobial agent against Mycobacterium tuberculosis (Mtb), without cytotoxicity. Mtb-IN-2 significantly decreases colony-forming units (CFU) in spleen of murine tuberculosis models, and distinguishes both drug-sensitive and drug-resistant Mtb H37Rv strains. Mtb-IN-2 affects methionine metabolism but not folate pathway directly.

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mtb-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC(O)=C(C(O)=O)C=C1)C2=NC3=C(C=C2)C=CC=C3

• Molecular Formula :

  C17H12N2O4

• Molecular Weight :

  308.29

• References & Citations :

  [1]Nawrot DE, et al. Antimycobacterial pyridine carboxamides: From design to in vivo activity. Eur J Med Chem. 2023 Oct 5;258:115617.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2861190-30-7]