Mtb-IN-10

• Description:

  Mtb-IN-10 (Compound P15) is a Rv1625c/Cya activator that regulates cAMP metabolism to influence the growth of Mycobacterium tuberculosis (Mtb) . Mtb-IN-10 exhibits an EC50 of 1.96 µM in an Mtb-infected macrophage model and demonstrates 58.0% oral bioavailability in mice at a 20 mg/kg dose. It may regulate intracellular signaling and disrupt cholesterol metabolism in Mtb, thereby inhibiting bacterial proliferation. Mtb-IN-10 holds potential for tuberculosis (TB) research, particularly for combating multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) Mtb strains[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  O=S (C1CCOCC1) (NC2=CC (C3=CSC=C3) =NO2) =O

• Molecular Formula:

  C12H14N2O4S2

• Molecular Weight:

  314.38

• References & Citations:

  [1]Martinez G, et al. Novel isoxazole thiophene-containing compounds active against Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2025 Apr 15;119:130108.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported