Mtb-IN-10

• Description :

  Mtb-IN-10 (Compound P15) is a Rv1625c/Cya activator that regulates cAMP metabolism to influence the growth of Mycobacterium tuberculosis (Mtb) . Mtb-IN-10 exhibits an EC50 of 1.96 µM in an Mtb-infected macrophage model and demonstrates 58.0% oral bioavailability in mice at a 20 mg/kg dose. It may regulate intracellular signaling and disrupt cholesterol metabolism in Mtb, thereby inhibiting bacterial proliferation. Mtb-IN-10 holds potential for tuberculosis (TB) research, particularly for combating multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) Mtb strains[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Smiles :

  O=S(C1CCOCC1)(NC2=CC(C3=CSC=C3)=NO2)=O

• Molecular Formula :

  C12H14N2O4S2

• Molecular Weight :

  314.38

• References & Citations :

  [1]Martinez G, et al. Novel isoxazole thiophene-containing compounds active against Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2025 Apr 15;119:130108.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported