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Mtb-IN-10

CAT: 0804-HY-170970Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-170970Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mtb-IN-10 (Compound P15) is a Rv1625c/Cya activator that regulates cAMP metabolism to influence the growth of Mycobacterium tuberculosis (Mtb) . Mtb-IN-10 exhibits an EC50 of 1.96 µM in an Mtb-infected macrophage model and demonstrates 58.0% oral bioavailability in mice at a 20 mg/kg dose. It may regulate intracellular signaling and disrupt cholesterol metabolism in Mtb, thereby inhibiting bacterial proliferation. Mtb-IN-10 holds potential for tuberculosis (TB) research, particularly for combating multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) Mtb strains[1].
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
O=S(C1CCOCC1)(NC2=CC(C3=CSC=C3)=NO2)=O
Molecular Formula
C12H14N2O4S2
Molecular Weight
314.38
References & Citations
[1]Martinez G, et al. Novel isoxazole thiophene-containing compounds active against Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2025 Apr 15;119:130108.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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