Mtb-IN-12

• Description :

  Mtb-IN-12 (Compound 5m) is a dual-target inhibitor that can target the CYP125 (KD: 40 nM; KI: 0.1 μM) and CYP142 (KD: 160 nM; KI: 0.05 μM) enzymes of Mycobacterium tuberculosis. Mtb-IN-12 exhibits good inhibitory activity against both drug-sensitive strains and multidrug-resistant tuberculosis strains, with low toxicity to macrophages. Mtb-IN-12 can be used in the research of anti-tuberculosis drugs[1].

• UNSPSC :

  12352005

• Target :

  Bacterial; Cytochrome P450

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Smiles :

  COC1=CC=C(CNC2=CC=C(C=C2)CC3=CC=NC=C3)C=C1

• Molecular Formula :

  C20H20N2O

• Molecular Weight :

  304.39

• References & Citations :

  [1]Kavanagh ME, et al. Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism. J Med Chem. 2025 Jul 24;68 (14) :14416-14441.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported