Mtb-IN-4

• Description :

  Mtb-IN-4 (compound 17h) is a nontoxic isoxazole, with anti-Mycobacterium tuberculosis (Mtb) activity (IC50=0.70 μM) . Mtb-IN-4 inhibits Mtb respiration and biofilm formation in macrophage, and enhances antibiotic isoniazid (INH) inhibition against INH-resistant Mtb mutant[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mtb-in-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1CSC2=C(C3CC3)C(C4=CC(C5=CC=C6C=CC=CC6=C5)=NO4)=CC(N21)=O)O

• Molecular Formula :

  C24H18N2O4S

• Molecular Weight :

  430.48

• References & Citations :

  [1]Sarkar S, et al. Design, Synthesis, and Evaluation of Novel Δ2-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant. J Med Chem. 2023 Aug 24;66 (16) :11056-11077.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2306039-13-2]