VRT-534

CAT: 0804-HY-149318-05Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-149318-05Size:100 mg

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Description

VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26) . Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].

CAS Number

926664-32-6

UNSPSC

12352005

Target

Connexin; Gap Junction Protein

Type

Reference compound

Related Pathways

Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/vrt-534.html

Purity

98.32

Solubility

10 mM in DMSO

Smiles

O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl

Molecular Formula

C25H24ClN3O4S

Molecular Weight

497.99

References & Citations

[1]Wang D, et al. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6 (7) :997-1005.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-2-thiazolyl]-cyclopropanecarboxamide

CAS Number	926664-32-6
PubChem CID	45480521
IUPAC Name	1-(1,3-benzodioxol-5-yl)-N-[5-[(S)-(2-chlorophenyl)-[(3R)-3-hydroxypyrrolidin-1-yl]methyl]-1,3-thiazol-2-yl]cyclopropane-1-carboxamide
Molecular Formula	C25H24ClN3O4S
Molecular Weight	498.0
XLogP	3.9
Topological Polar Surface Area	112
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Heavy Atom Count	34
Formal Charge	0
Complexity	758

SMILES

C1CN(C[C@@H]1O)[C@@H](C2=CC=CC=C2Cl)C3=CN=C(S3)NC(=O)C4(CC4)C5=CC6=C(C=C5)OCO6

InChI

InChI=1S/C25H24ClN3O4S/c26-18-4-2-1-3-17(18)22(29-10-7-16(30)13-29)21-12-27-24(34-21)28-23(31)25(8-9-25)15-5-6-19-20(11-15)33-14-32-19/h1-6,11-12,16,22,30H,7-10,13-14H2,(H,27,28,31)/t16-,22+/m1/s1

InChIKey

OUGLISSDQZYBGK-ZHRRBRCNSA-N

Chemical Structure

2D Structure

CAS: 926664-32-6

CID: 45480521

Formula: C25H24ClN3O4S

MW: 498.0

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	498.0
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	497.1176051
Monoisotopic Mass	497.1176051
Topological Polar Surface Area	112 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	758
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-112226-01	VRT-043198
HY-W953655	CRBN ligand-534
HY-112226R	VRT-043198 (Standard)
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HY-W074975R-01	CL 5343 (Standard)
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Alternative Products

Catalog	Name
T80852-01	VRT-534
TYD-03939-01	(R, R) -VRT-534
B5896-25	VRT-1353385
BV165183-01	VRT 043198
GTR19222686-01	VRT-18858
GTR19192440-01	VRT-325
BA6628-1	VRT-532
BA3378-50	VRT-043198

VRT-534

Chemical Information

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