VRT-534

• Description:

  VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26) . Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].

• UNSPSC:

  12352005

• Target:

  Connexin; Gap Junction Protein

• Type:

  Reference compound

• Related Pathways:

  Cytoskeleton

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/vrt-534.html

• Purity:

  98.32

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (C1 (C2=CC=C3C (OCO3) =C2) CC1) NC (S4) =NC=C4[C@@H] (N (CC5) C[C@@H]5O) C (C=CC=C6) =C6Cl

• Molecular Formula:

  C25H24ClN3O4S

• Molecular Weight:

  497.99

• References & Citations:

  [1]Wang D, et al. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6 (7) :997-1005.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  926664-32-6