VRT-534

CAT: 0804-HY-149318-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-149318-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26) . Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].
CAS Number
[926664-32-6]
UNSPSC
12352005
Target
Connexin; Gap Junction Protein
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vrt-534.html
Purity
98.32
Solubility
10 mM in DMSO
Smiles
O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl
Molecular Formula
C25H24ClN3O4S
Molecular Weight
497.99
References & Citations
[1]Wang D, et al. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6 (7) :997-1005.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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