VRT-534

• Description :

  VRT-534 (Compound 3) is a chemical chaperone targeting connexin 26 (Cx26) . Vrt-534 exhibits dose-responsive binding to recombinant WT Cx26 and mutant Cx26 K188N with EC50s of 19 and 5 μM, respectively. Vrt-534 can be used in research related to hearing impairment[1].

• UNSPSC :

  12352005

• Target :

  Connexin; Gap Junction Protein

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/vrt-534.html

• Purity :

  98.32

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1(C2=CC=C3C(OCO3)=C2)CC1)NC(S4)=NC=C4[C@@H](N(CC5)C[C@@H]5O)C(C=CC=C6)=C6Cl

• Molecular Formula :

  C25H24ClN3O4S

• Molecular Weight :

  497.99

• References & Citations :

  [1]Wang D, et al. A Chemical Chaperone Restores Connexin 26 Mutant Activity. ACS Pharmacol Transl Sci. 2023 Jun 1;6 (7) :997-1005.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [926664-32-6]