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CL 5343

CAT: 0804-HY-W074975-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W074975-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 ??renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer[1][2][3].
CAS Number
14949-00-9
Product Name Alternative
5-Amino-1,3,4-thiadiazole-2-sulfonamide
UNSPSC
12352005
Hazard Statement
H314, H318
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cl-5343.html
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=NN=C(N)S1)(N)=O
Molecular Formula
C2H4N4O2S2
Molecular Weight
180.21
Precautions
H314, H318
References & Citations
[1]Aday B, et al. Synthesis of novel 5-amino-1,3,4-thiadiazole-2-sulfonamide containing acridine sulfonamide/carboxamide compounds and investigation of their inhibition effects on human carbonic anhydrase I, II, IV and VII. Bioorg Chem. 2018 Apr;77:101-105.|[2]Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14 (4) :689-693.|[3]Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11 (8) : 2243-2264.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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