VRT-043198 (Standard)

• Description:

  VRT-043198 (Standard) is the analytical standard of VRT-043198. This product is intended for research and analytical applications. VRT-043198, the agent metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively[1].

• UNSPSC:

  12352005

• Target:

  Caspase; Drug Metabolite; Reference Standards

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease; Others

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C (N[C@H] (C=O) CC (O) =O) [C@H]1N (C ([C@H] (C (C) (C) C) NC (C2=CC=C (N) C (Cl) =C2) =O) =O) CCC1

• Molecular Formula:

  C22H29ClN4O6

• Molecular Weight:

  480.94

• References & Citations:

  [1]Woods Wannamaker, et al. (S) -1- ((S) -2-{[1- (4-amino-3-chloro-phenyl) -methanoyl]-amino}-3,3-dimethyl-butanoyl) -pyrrolidine-2-carboxylic acid ((2R,3S) -2-ethoxy-5-oxo-tetrahydro-furan-3-yl) -amide (VX-765), an orally available selective interleukin (IL) -converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. J Pharmacol Exp Ther. 2007 May;321 (2) :509-16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  244133-31-1