VRT-532

CAT: 0804-HY-114725-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-114725-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].
CAS Number
[38214-71-0]
Product Name Alternative
CFpot-532
UNSPSC
12352005
Hazard Statement
H302, H318
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vrt-532.html
Purity
98.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C=CC(C)=C1)=C1C2=NNC(C3=CC=CC=C3)=C2
Molecular Formula
C16H14N2O
Molecular Weight
250.30
Precautions
H302, H318
References & Citations
[1]Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418 (1) :185-90. |[2]Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR) -processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282 (46) :33247-33251.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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