VRT-532

• Description :

  VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].

• Product Name Alternative :

  CFpot-532

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H318

• Target :

  CFTR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/vrt-532.html

• Purity :

  98.98

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(C=CC(C)=C1)=C1C2=NNC(C3=CC=CC=C3)=C2

• Molecular Formula :

  C16H14N2O

• Molecular Weight :

  250.30

• Precautions :

  H302, H318

• References & Citations :

  [1]Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418 (1) :185-90. |[2]Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR) -processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282 (46) :33247-33251.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [38214-71-0]