VRT-532

• Product Name Alternative:

  Vatensol, (±)-Pirmenol (hydrochloride); CI-845

• UNSPSC Description:

  VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].

• Target Antigen:

  CFTR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/vrt-532.html

• Purity:

  98.98

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC(C=CC(C)=C1)=C1C2=NNC(C3=CC=CC=C3)=C2

• Molecular Weight:

  250.30

• References & Citations:

  [1]Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. |[2]Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  38214-71-0