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VRT-325

CAT: 0804-HY-119229-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119229-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VRT-325 is a novel small molecule discovered by screening a compound library designed to address the genetic defect in cystic fibrosis (CF) caused by the ΔF508 mutation in CFTR. VRT-325 belongs to a class of compounds that promote ΔF508-CFTR efflux from the endoplasmic reticulum and restores chloride transport levels in epithelial cells of CF-derived bronchi[1].
CAS Number
815592-21-3
Product Name Alternative
4-Hydroxy-TEMPO-d17,15N
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vrt-325.html
Purity
99.15
Smiles
CC(N1CCN(CC1)S(=O)(C2=CC=C(C=C2)OC)=O)C3=NC(OC4CCCCC4)=C5C=CC=CC5=N3
Molecular Formula
C27H34N4O4S
Molecular Weight
510.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Van Goor F, et al. Rescue of ﾎ508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules[J]. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006, 290 (6) : L1117-L1130.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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