KTX-497

KTX-497

• CAS Number: 2432993-46-7
• UNSPSC Description: KTX-497 is an IRAK4 PROTAC degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1].(Pink:IRAK4 inhibitor (HY-150735); Black: linker; Blue: CRBN Ligand (HY-10984))
• Target Antigen: IRAK; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ktx-497.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC4CC5(CCN(CC5)C[C@@H]6CC[C@@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)C4)=C3C1=O
• Molecular Weight: 854.92
• References & Citations: [1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported