KTX-497

• Description :

  KTX-497 is an IRAK4 PROTAC degrader with a DC50 value of 3 nM. KTX-497 can be used for the research of oncology[1]. (Pink:IRAK4 inhibitor (HY-150735) ; Black: linker; Blue: CRBN Ligand (HY-10984) )

• UNSPSC :

  12352005

• Target :

  IRAK; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ktx-497.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(NC4CC5(CCN(CC5)C[C@@H]6CC[C@@H](N7C=C8C(C=C(C(NC(C9=CC=CC(C(F)(F)F)=N9)=O)=C8)C(C)(O)C)=N7)CC6)C4)=C3C1=O

• Molecular Formula :

  C45H49F3N8O6

• Molecular Weight :

  854.92

• References & Citations :

  [1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IRAK4

• CAS Number :

  [2432993-46-7]