KTX-612

• Description :

  KTX-612 is an orally active IRAK4 PROTAC degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1]. (Pink:IRAK4 inhibitor (HY-150735) ; Black: linker; Blue: CRBN Ligand (HY-10984) )

• UNSPSC :

  12352005

• Target :

  IRAK; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ktx-612.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7

• Molecular Formula :

  C46H51F3N8O6

• Molecular Weight :

  868.94

• References & Citations :

  [1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IRAK4

• CAS Number :

  [2573298-14-1]