KTX-612

• Description:

  KTX-612 is an orally active IRAK4 PROTAC degrader with a DC50 value of 7 nM. KTX-612 can be used for the research of oncology[1]. (Pink:IRAK4 inhibitor (HY-150735) ; Black: linker; Blue: CRBN Ligand (HY-10984) )

• UNSPSC:

  12352005

• Target:

  IRAK; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ktx-612.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(O)C1=CC2=NN(C=C2C=C1NC(C3=CC=CC(C(F)(F)F)=N3)=O)[C@H](CC4)CC[C@@H]4CN(CC5)CCC5(C6)CC6CNC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8=O)=O)=CC=C7

• Molecular Formula:

  C46H51F3N8O6

• Molecular Weight:

  868.94

• References & Citations:

  [1]Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IRAK4

• CAS Number:

  [2573298-14-1]