KTX-Sp2

• Description :

  KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca2+ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells[1].

• UNSPSC :

  12352209

• Target :

  Potassium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ktx-sp2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](N)CO)N1[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCCN)=O)=O)CC4=CNC=N4)=O)[C@@H](C)O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)CCCNC(N)=N)=O)CSSC[C@H](NC6=O)C(N[C@H](C(NCC(O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CCC2)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CSSC[C@H](NC8=O)C(N[C@H]6CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CO)=O)CO)=O)CO)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]8CCCNC(N)=N)=O)=O)CC(N)=O)=O)CCSC)=O)=O)CCCCN)=O)C)=O)=O)CC9=CNC=N9)=O)CC(C)C)=O)CCC1

• Molecular Formula :

  C155H244N58O49S7

• Molecular Weight :

  3928.41

• References & Citations :

  [1]Zhang Y, et al. Immunosuppressive effects of a novel potassium channel toxin Ktx-Sp2 from Scorpiops Pocoki. Cell Biosci. 2019 Dec 16;9:99.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported