KTX-Sp2

CAT: 0804-HY-P5870Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P5870Size:1 Each
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Description
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca2+ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells[1].
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ktx-sp2.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CO)N1[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCCN)=O)=O)CC4=CNC=N4)=O)[C@@H](C)O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)CCCNC(N)=N)=O)CSSC[C@H](NC6=O)C(N[C@H](C(NCC(O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)CCC2)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CSSC[C@H](NC8=O)C(N[C@H]6CCCNC(N)=N)=O)=O)CCC(N)=O)=O)CC(N)=O)=O)CO)=O)CO)=O)CO)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]8CCCNC(N)=N)=O)=O)CC(N)=O)=O)CCSC)=O)=O)CCCCN)=O)C)=O)=O)CC9=CNC=N9)=O)CC(C)C)=O)CCC1
Molecular Formula
C155H244N58O49S7
Molecular Weight
3928.41
References & Citations
[1]Zhang Y, et al. Immunosuppressive effects of a novel potassium channel toxin Ktx-Sp2 from Scorpiops Pocoki. Cell Biosci. 2019 Dec 16;9:99.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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