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KTX-582

CAT: 0804-HY-148274-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148274-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KTX-582 is a potent IRAK4 degrader with DC50 values of 4 nM and 5 nM for IRAK4 and Ikaros, respectively. KTX-582 can induce apoptosis in MYD88MT DLBCL, and is efficient to induce in vivo tumor regressions in lymphoma model[1][2][3].
CAS Number
2573298-13-0
UNSPSC
12352005
Target
Apoptosis; IRAK; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-582.html
Purity
98.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC(C(F)(F)F)=CC=C1)NC2=CC3=CN([C@H]4CC[C@H](CN(CCCO[C@H]5C[C@H](NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)C5)C)CC4)N=C3C=C2C(C)(O)C
Molecular Formula
C45H51F3N8O7
Molecular Weight
872.93
References & Citations
[1]Matthew Weiss. Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications. Northeastern Section, ACS (NESACS) .|[2]Jennifer K. Lue, MD . Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations. American Society of Hematology ASH Annual Meeting|[3]Nello Mainolfi, et al. Irak degraders and uses thereof. WO/2020/113233|[4]Vogelmann A, Robaa D, Sippl W, Jung M. Proteolysis targeting chimeras (PROTACs) for epigenetics research. Curr Opin Chem Biol. 2020 Aug;57:8-16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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