KTX-582 intermediate-2

• Description :

  KTX-582 intermediate-2 is an intermediate in the synthesis of KTX-582 (HY-148274) and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Type :

  ADC Related

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ktx-582-intermediate-2.html

• Purity :

  96.18

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@H]4C[C@@H](C4)OCCCNC)=C3C1=O.Br

• Molecular Formula :

  C21H27BrN4O5

• Molecular Weight :

  495.37

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2022147465 A1. 2022-07-07.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [2434850-07-2]