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KTX-582 intermediate-2

CAT: 0804-HY-49432-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-49432-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KTX-582 intermediate-2 is an intermediate in the synthesis of KTX-582 and can be used for ADC preparation. KTX-582 is an IRAK4 degrader and inducer of apoptosis with DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively[1].
CAS Number
2434850-07-2
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
ADC Related
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ktx-582-intermediate-2.html
Purity
96.18
Solubility
10 mM in DMSO
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@H]4C[C@@H](C4)OCCCNC)=C3C1=O.Br
Molecular Formula
C21H27BrN4O5
Molecular Weight
495.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Mainolfi, et al. Preparation of heterocycles as IRAK degraders and uses thereof. World Intellectual Property Organization, WO2022147465 A1. 2022-07-07.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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