hCAIX-IN-10

hCAIX-IN-10

• CAS Number: 2497504-72-8
• UNSPSC Description: hCAIX-IN-10 (Compound 6i) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 61.5 and 586.8 nM for hCA IX and hCA XII, respectively. ?hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].
• Target Antigen: Carbonic Anhydrase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hcaix-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C2=CC=CC(C)=C2)C(C3=CN(C4=CC=CC=C4)N=C3C5=CC6=CC=CC=C6OC5=O)SC1
• Molecular Weight: 479.55
• References & Citations: [1]Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported