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BACE1/2-IN-1

CAT: 0804-HY-147758Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147758Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BACE1/2-IN-1 (compound 34) is a potent BACE1 and BACE2 inhibitor, with an IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 shows a combination of lower Pgp efflux ratio and improved passive permeability. BACE1/2-IN-1 displays reduced liver microsomal metabolic stability[1].
CAS Number
2671036-34-1
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-2-in-1.html
Solubility
10 mM in DMSO
Smiles
NC1=N[C@](CN(C2=NC=CC=N2)C3)([C@]4([H])C[C@]4(C(C)(C)OC[C@@H]5C[C@H]5C)[H])[C@@H]3CS1
Molecular Formula
C21H31N5OS
Molecular Weight
401.57
References & Citations
[1]Winneroski LL, et al. Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints. Bioorg Med Chem. 2020 Jan 1;28 (1) :115194.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; BACE2

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