BACE1/2-IN-1

• Target:

  Beta Amyloid|||Beta-Secretase|||Others

• Related Pathways:

  Neuroscience|||Others

• Bioactivity:

  BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 values of 0.01 and 0.0053 ?M, respectively. It exhibits a lower Pgp efflux ratio, improved passive permeability, and decreased metabolic stability in liver microsomes.

• Smiles:

  C(OC[C@H]1[C@H](C)C1)(C)(C)[C@H]2[C@]([C@@]34[C@@](CN(C3)C=5N=CC=CN5)(CSC(N)=N4)[H])(C2)[H]

• Molecular Formula:

  C21H31N5OS

• Molecular Weight:

  401.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2671036-34-1