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BACE1-IN-2

CAT: 0804-HY-112444Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112444Size:1 Each
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Description
BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1].
CAS Number
1352416-78-4
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BACE1-IN-2.html
Solubility
10 mM in DMSO
Smiles
NC1=N[C@@](C2=C(F)C=CC(NC(C3=CC=C(C#N)C=N3)=O)=C2)(C)[C@H](C(F)(F)F)OC1
Molecular Formula
C19H15F4N5O2
Molecular Weight
421.35
References & Citations
[1]Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61 (12) :5292-5303.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1

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