BACE1-IN-2

• Description :

  BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM[1].

• UNSPSC :

  12352005

• Target :

  Beta-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/BACE1-IN-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=N[C@@](C2=C(F)C=CC(NC(C3=CC=C(C#N)C=N3)=O)=C2)(C)[C@H](C(F)(F)F)OC1

• Molecular Formula :

  C19H15F4N5O2

• Molecular Weight :

  421.35

• References & Citations :

  [1]Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61 (12) :5292-5303.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  BACE1

• CAS Number :

  [1352416-78-4]