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ATR-IN-18

CAT: 0804-HY-147570Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147570Size:1 Each
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Description
ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity[1].
CAS Number
2766407-55-8
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atr-in-18.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.CS(=O)(N1C2=C(CC1)C(N3[C@@H](COCC3)C)=NC4=C2C=NN4C5=NNC=C5)=O
Molecular Formula
C19H22F3N7O5S
Molecular Weight
517.48
References & Citations
[1]Xiaohui Liu, et al. Triheterocyclic derivative, and pharmaceutical composition and application thereof. WO2022078480A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATR

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