PROTAC AR Degrader-6

PROTAC AR Degrader-6

• CAS Number: 2753650-84-7
• UNSPSC Description: PROTAC AR Degrader-6 (Compound 1) is a PROTAC androgen receptor degrader (DC50: 10 nM in VCaP cell). PROTAC AR Degrader-6 blocks the process of androgen receptor transduction and also degrades the receptor itself. PROTAC AR Degrader-6 can be used for prostate cancer research. Pink: AR ligand (HY-130845); Blue: E3 ligase ligand (HY-W1003189); Black: linker (HY-169975)[1].
• Target Antigen: Androgen Receptor; PROTACs
• Type: Reference compound
• Related Pathways: PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/androgen-receptor-degrader-3.html
• Purity: 95.00
• Solubility: DMSO : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N(C6C(NC(CC6)=O)=O)N=C7)=O)C7=C5)CC4)C=C2)=O)[C@H]1OC8=CC(Cl)=C(C=C8)C#N
• Molecular Weight: 819.39
• References & Citations: [1]Lu H.F, et al. 酞嗪酮类化合物及其制备方法和医药用途. China, WO2021249534 A1.2021-12-16.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, protect from light, stored under nitrogen)
• Clinical Information: No Development Reported