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Antimalarial agent 11

CAT: 0804-HY-146769Size: 1 EachDry Ice: NoHazardous: No
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Description
Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively[1].
CAS Number
1214454-56-4
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-11.html
Solubility
10 mM in DMSO
Smiles
OC(CN1CCC2(CC(O)C3=C(O2)C4=C(C=CC=C4)C=C3)CC1)C5=CC=C(F)C(F)=C5
Molecular Formula
C25H25F2NO3
Molecular Weight
425.47
References & Citations
[1]Iredia D Iyamu, et al. Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity. Bioorg Med Chem. 2022 Mar 1;57:116629.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

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