HDAC-IN-37

CAT: 0804-HY-146750Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-146750Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-37 is a potent HDAC inhibitor with IC50s of 0.0551 μM, 1.24 μM, 0.948 μM and 34.2 μM for HDAC1, HDAC3, HDAC8 and HDAC6, respectively. HDAC-IN-37 induces histone acetylation in a slow-off manner. HDAC-IN-37 prevents cell transition from G1 phase to S phase and induces early cell apoptosis[1].
CAS Number
[2766466-56-0]
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-37.html
Solubility
10 mM in DMSO
Smiles
CCCCNC1=C2N=CN(C2=NC(Cl)=N1)CC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O
Molecular Formula
C23H24ClN7O
Molecular Weight
449.94
References & Citations
[1]Mao PT, He WB, Mai X, et al. Synthesis and biological evaluation of aminobenzamides containing purine moiety as class I histone deacetylases inhibitors. Bioorg Med Chem.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC3; HDAC6; HDAC8

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