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HDAC6-IN-37

CAT: 0804-HY-158030Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158030Size:1 Each
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Description
HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue[1].
CAS Number
2986486-82-0
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac6-in-37.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C(C=C1)CN2C3=CC=CC=C3SC4=C2C=CC=C4)NO.Cl
Molecular Formula
C19H16ClN3O2S
Molecular Weight
385.87
References & Citations
[1]Liu R, et al. Study on multi-target effects of the novel HDAC6 inhibitor W5 on Aβ/Cu2+-induced Alzheimer's disease model of rats. Brain Res. 2024 Mar 3;1832:148847.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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