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MtTMPK-IN-5

CAT: 0804-HY-146699Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146699Size:1 Each
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Description
MtTMPK-IN-5 (compound 17) is a potent M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 34 μM. MtTMPK-IN-5 combines favorable enzyme inhibitory activity with significant activity against M. tuberculosis (MIC = 12.5 μM) . MtTMPK-IN-5 can be used for researching tuberculosis[1].
CAS Number
2987763-18-6
UNSPSC
12352005
Target
Bacterial; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mttmpk-in-5.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC=CC(C4=CC=CC=N4)=N3
Molecular Formula
C21H23N5O2
Molecular Weight
377.44
References & Citations
[1]Jian Y, et al. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur J Med Chem. 2020;206:112659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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