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MtTMPK-IN-2

CAT: 0931-T62305-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62305-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2799607-71-7
Target
Others, DNA/RNA Synthesis, Antibacterial
Related Pathways
Cell Cycle/Checkpoint, Others, Microbiology/Virology, DNA Damage/DNA Repair
Bioactivity
MtTMPK-IN-2 (compound 15), a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), demonstrates an IC50 value of 1.1 μM. This compound effectively inhibits Mtb H37Rv with a minimum inhibitory concentration (MIC) of 12.5 μM and exhibits cytotoxicity in MRC-5 human fibroblast cells with an EC50 of 6.1 μM. MtTMPK-IN-2 is valuable for tuberculosis research [1].
Smiles
O=C1N(C2CCN(CC3=CC(OC4=CC(Cl)=CC=C4)=CC=C3)CC2)C=C(C)C(=O)N1
Molecular Formula
C23H24ClN3O3
Molecular Weight
425.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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