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MtTMPK-IN-7

CAT: 0804-HY-146701Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146701Size:1 Each
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Description
MtTMPK-IN-7 (compound 26) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 47 μM. MtTMPK-IN-7 has sub-micromolar activity against mycobacteria (MICs = 2.3~4.7 μM) without significant cytotoxicity. MtTMPK-IN-7 can be used for researching tuberculosis[1].
CAS Number
2987482-25-5
UNSPSC
12352005
Target
Bacterial; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mttmpk-in-7.html
Solubility
10 mM in DMSO
Smiles
CCC1=C(N2C=C(C=CC2=N1)Cl)C(NCC3=CC=C(C=C3)N4CCC(CC4)N5C=C(C(NC5=O)=O)C)=O
Molecular Formula
C27H29ClN6O3
Molecular Weight
521.01
References & Citations
[1]Jian Y, et al. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur J Med Chem. 2020;206:112659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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