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MtTMPK-IN-1

CAT: 0804-HY-144663Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144663Size:1 Each
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Description
MtTMPK-IN-1 (compound 3) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 2.5 μM. MtTMPK-IN-1 has moderate to weak activity against Mtb H37Rv and low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 can be used for researching tuberculosis[1].
CAS Number
2799607-58-0
UNSPSC
12352005
Target
Bacterial; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mttmpk-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=NC(OC4=CC=CC=C4)=CC=C3
Molecular Formula
C22H24N4O3
Molecular Weight
392.45
References & Citations
[1]Song L, et al. Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors. Eur J Med Chem. 2021;225:113784.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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