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MtTMPK-IN-9

CAT: 0804-HY-146703Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146703Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MtTMPK-IN-9 (compound 28) is a moderate M. tuberculosis thymidylate kinase (MtbTMPK) inhibitor with an IC50 value of 48 μM. MtTMPK-IN-9 has sub-micromolar activity against mycobacteria (MICs = 6.25~9.4 μM) without significant cytotoxicity. MtTMPK-IN-9 can be used for researching tuberculosis[1].
CAS Number
2987299-68-1
UNSPSC
12352005
Target
Bacterial; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mttmpk-in-9.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC=C(C=C3)CNC(C4=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C4)=O
Molecular Formula
C25H26N6O7
Molecular Weight
522.51
References & Citations
[1]Jian Y, et al. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur J Med Chem. 2020;206:112659.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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