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MtTMPK-IN-3

CAT: 0804-HY-144665Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144665Size:1 Each
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Description
MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM) . MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM) . MtTMPK-IN-3 can be used for researching tuberculosis[1].
CAS Number
2799607-80-8
UNSPSC
12352005
Target
Bacterial; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mttmpk-in-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC(Cl)=CC(Cl)=C4)=CC=C3
Molecular Formula
C23H23Cl2N3O3
Molecular Weight
460.35
References & Citations
[1]Song L, et al. Structure-aided optimization of non-nucleoside M. tuberculosis thymidylate kinase inhibitors. Eur J Med Chem. 2021;225:113784.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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